By Martyn Herman
Even with more than 80 percent of his first serves finding the target, a statistic that would normally spell trouble for an opponent, he walked off a 6-3 6-1 loser, his pride dented after a Murray masterclass.
Former world number one Roddick is nothing if not resilient, though, and despite the thrashing he will arrive at Wimbledon next week as one of a smallish group of players capable of surviving until deep into the second week.
"I think it's about fine tuning more than re-inventing the wheel next week," Roddick, who beat Murray in the 2009 Wimbledon semi-finals, told reporters.
"I think he did a lot right today. I don't think I did a whole lot wrong.
"I felt like I hit the ball well. My serve, I haven't seen it, but I had to be close to 70 percent. I remember missing one second serve return. I felt like I missed a bunch of chips and stuff by an inch or two.
"It certainly does nothing to my confidence level going into Wimbledon. I just thought he played too good today."
Roddick elected to miss the French Open on his least favored surface because of a shoulder injury after consecutive first round defeats on clay in Madrid and Rome.
After a couple of months without a win, the world number 10 said it was a good feeling to arrive at his favorite part of the year feeling fit and healthy.
"I felt really good when I got here, but after having not, you know, played well for two months or so, getting that to translate wasn't always an easy thing," he said.
"I thought I played well. Got four matches, which is really important, and I feel prepared going into the practice week for Wimbledon, so it was a good week for me."
(Reporting by Martyn Herman; Editing by Brian Homewood)